HF events

Depression associated with increased risk of heart failure events and sudden cardiac death in hypertrophic cardiomyopathy

By Ahmed El-Medany

Hu at al sought to investigate the impact of depression on clinical outcomes in individuals with hypertrophic cardiomyopathy (HCM). 820 participants were recruited between January 2014 and December 2017. Sudden cardiac death (SCD) and HCM-related heart failure (HF) were defined as end points.

‘A Chinese version of the Structured Clinical Interview followed the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition and was used to diagnose depression’, the authors explain.

Figure 1.  Flowchart of the screening process and dropouts of the current cohort study. COPD indicates chronic obstructive pulmonary disease.

Figure 2 (right). Kaplan–Meier curves for sudden cardiac death events and hypertrophic cardiomyopathy–related heart failure events in patients with and without depression.

During follow‐up, SCD events occurred in 75 (9%) individuals (21.8 per 1000 person‐years), and HCM‐related heart failure events developed in 149 (18%) individuals (43.3 per 1000 person‐years).

Kaplan–Meier curves showed a significant association of depression disorders with SCD events (p=0.001) and HCM‐related HF events (p=0.005).

Multivariate Cox regression analysis indicated that depression was an independent predictor of SCD events and HCM‐related HF events (41.9 versus 21.7 per 1000 person‐years; adjusted hazard ratio [HR], 1.9; 95% CI, 1.6–2.3; p<0.001; and 69.9 versus 38.6 per 1000 person‐years; HR, 1.8; 95% CI, 1.6–2.1; p<0.001, respectively).

Read more on this at the Journal of the American Heart Association website

Hu HL, Chen H, Zhu CY, Yue X, Wang HW, Qian G, Zhai CL, He CJ. Association Between Depression and Clinical Outcomes in Patients With Hypertrophic Cardiomyopathy. Journal of the American Heart Association. 9 April 2021. Images credit: Journal of the American Heart Association.